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Huiyong Yin

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Articles

Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma

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By Yanhong Ding, Bowen Yu, Yongqiang Wang, Tongbin Gao, Huiyong Yin, Zhenhua Li, Shuzhen Liu, Guohua Yu, Ningning Wang
| Nature Verified
Abstract Clear cell renal cell carcinoma (ccRCC) exhibits a paradoxical fructose metabolism signature characterized by upregulation of the fructose transporter GLUT5 alongside downregulation of the catabolic enzymes (ketohexokinase, aldolase B, and triokinase), a pattern associated with poor prognosis.
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HMGCS1 drives cholesterol-dependent membrane repair and shields tumor cells from lymphocyte attack

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By Yajuan Zhang, Siyao Wang, Tianhang Luo, Haitang Yang, Yongqiang Wang, Yifei Zhu, Xin Zhou, Hong Gao, Yun Zhao, Zhengjiang Zhu, Huiyong Yin, Guangchuan Wang, Chenqi Xu, Xiujuan Qu, Feng Yao, Weiwei Yang, Tong Rong, Miaowen Zou, Qizhen Fei, Zhonggang Shi
| Nature Verified
Abstract Cytotoxic lymphocytes use perforin to form plasma membrane (PM) pores in tumor cells, thereby enabling granzyme-mediated cell death. However, whether and how tumor metabolism enables PM repair to evade immunity is unclear. In this study, using a functional screen targeting 111 metabolic enzymes, we identified hydroxymethylglutaryl-CoA synthase 1 (HMGCS1) as critical for repairing perforin-induced PM damage.
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Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis

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By Yongqiang Wang, Xiangyang Zhang, Ningning Wang, Huimin Jiang, Ningning Liang, Chenxi Du, Chunzhao Yin, Rui Li, Lili Zhang, Jingwen Lv, Haoran Ma, Xiaodong Xu, Xinran Kong, Xin McRae Chen, Guijun Liu, Shiting Chen, Hualing Xu, Jun Qin, Shengxian Li, Yongzhen Tao, Shan Zeng, Hong Shen, Marcus D. Goncalves, Shanshan Zhong, Huiyong Yin, Qiaochu Tu
| Nature Verified
Abstract Fructose consumption increases the risk of obesity-related metabolic diseases and some cancers, but its role in hepatocellular carcinogenesis (HCC) remains controversial. Animal studies suggest that high fructose promotes HCC, whereas human data fail to support the positive link between fructose intake and elevated risk of liver cancer.
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