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Humera Gull

As seen in: BioRxiv
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Articles

Gain of Function Cytolysin Variant Expressed by Clinically Isolated Urinary Enterococcus faecalis

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By Neha V. Hulyalkar, Ibrahim Salaudeen, Humera Gull
| BioRxiv
Abstract Cytolysin is a toxin-bacteriocin commonly encoded by Enterococcus faecalis that can target erythrocytes, neutrophils, and macrophages as well as other Gram-positive bacteria. Cytolysin can lyse human, horse, rabbit, and mouse erythrocytes, but not sheep erythrocytes (SEs). It is hypothesized that SEs are resistant to cytolysin because they lack phosphatidylcholine (PC) in their membranes, while susceptible erythrocytes have PC-rich membranes, suggesting PC as a cytolysin binding target.
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