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Articles

4-Hydroxycinnamic acid and Itaconic acid exhibit broad spectrum synergy with conventional antibiotics in inhibiting multidrug-resistant Salmonella Typhimurium

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By Hunter Sheffield, Hina Khan, Priti Mudgil, Ihab Habib, Laura Huber, Akmal Nazir, Shabarinath Srikumar, Bismi Phasaludeen, Kripa Pancholi, Greeshma Bharathan, Dania Mustafa Darwich, RJeff Buhr
| Nature Verified
Abstract One approach to combating the surge in bacterial antimicrobial resistance is to use adjuvants that sensitize drug-resistant strains to conventional antibiotics. Here, we evaluated 24 pure bioactive compounds for their antibiotic adjuvant activity against a multidrug-resistant strain of Salmonella Typhimurium (DT104). All 24 bioactive compounds exhibited measurable antibacterial activity against DT104, with MIC values ranging from 0.036 to 4 mg/mL.
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