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Discovery of VU6083859, a TAOK1 Selective Inhibitor, and VU6080195, a pan-TAOK Activator

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By Daniel Schultz, Lauren Parr, Hunter Sweet, Sean Lamb
| ACS Publications
Introduction Click to copy section linkSection link copied! Thousand and one kinases (TAOKs), consisting of three family members (TAOK1, TAOK2, and TAOK3), are serine/threonine kinases within the STE20 kinase family. Each kinase shares a conserved N -terminal kinase domain, coiled-coil motifs, and a serine-rich domain, whereas TAOK2 is distinguished by an additional C -terminal leucine-rich repeat domain.
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