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Hussein Abdul Nabi on Muck Rack

Hussein Abdul Nabi

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Articles

Genotype-first analysis redefines autosomal dominant LZTR1 -related disorders susceptibility architecture

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By Bukola A. Olarewaju, David Melville, Ehab Y. Harahsheh, Meghan Carr, Marlene Girardo, Fadi E. Shamoun, Radhika Dhamija, Shelley S. Noland, Bernard R. Bendok, Mark R. Pittelkow, Maciej M. Mrugala, Alyx B. Porter, Masoud Hayatdavoodi, Linnea M. Baudhuin, Mohammad Karam Chaaban, Hussein Abdul Nabi, Yaqqira Womack, Majd Chaaban, Kristina R. Dandurand, Misha B. Asif, Dusica Babovic-Vuksanovic, Mayowa A. Osundiji
| Nature Verified
Abstract LZTR1-associated syndromes have defined the clinical recognition of this gene, yet its population susceptibility architecture remains unclear. Here we combined population-scale variant data, systematic literature curation, standardized ACMG/AMP interpretation, and allele-frequency modeling to evaluate dominant LZTR1-associated susceptibility using a genotype-first framework. We analyzed 4,930 LZTR1 variants from gnomAD and curated 181 reported variants from 50 publications.
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