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Huxuan Chen

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Articles

TCR-JANUS engager proteins enable bispecific targeting to overcome tumor heterogeneity in TCR-T cell therapy

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By DeNard V Simmons, Dongjun Li, Theo Bourdais, Chenxi Cheng, Ting Liang, Pengju Yao, Wenling Wang, Xiaowen Li, Ying Tian Verified, Jie Wang, Danli Xie, Fuming Qiu, Shuguang Tan, Huxuan Chen
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract T cell receptor (TCR)–based immunotherapy is limited by tumor antigen heterogeneity, which frequently leads to relapse. We developed a bispecific TCR-JANUS engager that functions synergistically with TCR engineered T cells (TCR-T).
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