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Hwanjun Yoon

As seen in: Pharma's Almanac
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Articles

Optimized Residual dsRNA Detection for mRNA Therapeutics

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By Namhyun Kim, Ahyeon Hwang, Hwanjun Yoon, Sukhwan Kim
| Pharma's Almanac Verified
The Implications of dsRNA in mRNA Therapeutics Most mRNA therapeutics and vaccines are synthesized through in vitro transcription (IVT) from DNA templates. During this process, double-stranded RNA (dsRNA) can be inadvertently produced as a by-product. This form of RNA, particularly when derived from a virus, is highly immunogenic; it activates several intracellular and endosomal sensors that can trigger inflammation, halt protein synthesis, and even lead to cell death.
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