Hyae Ran Byun on Muck Rack

Hyae Ran Byun

As seen in: Nature, Frontiers
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Articles

Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer’s disease in 5xFAD mice - Nature Aging

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By Hyae Ran Byun
| Nature Verified
Abstract Genome-wide association studies have identified many gene polymorphisms associated with an increased risk of developing late-onset Alzheimer’s disease (LOAD). Many of these LOAD risk-associated alleles alter disease pathogenesis by influencing innate immune responses and lipid metabolism of microglia (MG).
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Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking.

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By Hyae Ran Byun, Andrew Gomez, Shaogen Wu, Ghulam Muhammad
| biorxiv.org
Abstract Genome-wide association studies (GWAS) have identified many gene polymorphisms associated with an increased risk of developing Late Onset Alzheimer's Disease (LOAD). Many of these LOAD risk-associated alleles alter disease pathogenesis by influencing microglia innate immune responses and lipid metabolism pathways.
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Zinc Finger Proteins in Neuro-Related Diseases Progression

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By Teresa Jover-Mengual, Wei-Jye Lin, Hyae Ran Byun, Siyuan Bu
| Frontiers
The Definition, Structure, and Classification of Zinc Finger Proteins The first zinc finger protein was discovered as a transcription factor in 1985 by Alan Klug of the Laboratory of Molecular Biology in Cambridge, England. Zinc finger proteins (ZNF) can form transcription initiation complexes that bind to DNA-specific regions and mediate transcription. ZNF mainly rely on Zn2+ to form a stable structure similar to “finger” (Berg and Shi, 1996).
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