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Hye Gwang Jeong

As seen in: Nature
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Articles

The heat-killed bacteria consortium containing Akkermansia muciniphila and Bacteroides vulgatus attenuates diet-induced obesity in mice

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By Sung Jae Jang, Bo-Ram Cho, Su Hwang, Seung Yeon Lee, Gi Ho Lee, Kyung Lee, Cheonghoon Lee, HyungJin Lee, Hye Gwang Jeong, Sungjun Park, Gwang Pyo Ko
| Nature Verified
Abstract Mucin-degrading bacteria (MDB), such as Akkermansia muciniphila (A. muciniphila) and Bacteroides vulgatus (B. vulgatus), improve metabolic health but raise safety concerns due to mucus barrier degradation. Heat-killed bacteria, which retain beneficial cell components and metabolites without harmful activity, have gained attention. This study examined metabolic effects of the heat-killed consortium containing A. muciniphila and B. vulgatus in high-fat diet-induced obese mice.
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Discovery of a novel envelope protein derived from simian retrovirus 2 for pseudotyping retroviral vectors used for production of CAR immune cells

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By Hye Gwang Jeong, Moonjung Jeun, Yeongrin Kim, Heung Kyoung Lee, Ji U Choi
| Nature Verified
Abstract In this study, we develop a simian retrovirus 2 pseudotyped retrovirus (SRV2 RV) for the generation of CAR-based immune cells. The SRV2 RV exhibits superior gene transduction efficiency in both T cells and NK cells compared to feline endogenous retrovirus (RD114) pseudotyped retrovirus (RD114 RV) or vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped lentivirus (VSV-G LV). Among the various SRV pseudotypes tested, only the SRV2 RV successfully transduces genes into immune cells.
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