Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Hyoungjun Ham
"Germline Mutations in a G Protein Identify Signaling Cross-Talk in T C" by Hyoungjun Ham, Huie Jing et al.
Keywords Humans, Cell Movement, Cell Proliferation, Germ-Line Mutation, GTP-Binding Protein alpha Subunit, Gi2, Immunity, MAP Kinase Signaling System, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, ras GTPase-Activating Proteins, ras Proteins, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Pedigree Abstract Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways.
Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control - Nature Communications
Abstract During infection and cancer, mTORC1-mediated metabolic regulation impacts CD8+ T cell effector expansion and memory development. However, the mechanisms by which CD8+ T cells regulate mTORC1 to support their unique metabolic requirements remain unknown.
Germline mutations in a G protein identify signaling cross-talk in T cells
Research ExplorerPublicationsGermline mutations in a G protein identify signaling cross-t... Abstract Bibliographical data
Twenty years of microplastics pollution research-what have we learned?
Abstract Twenty years after the first publication using the term microplastics, we review current understanding, refine definitions and consider future prospects. Microplastics arise from multiple sources including tires, textiles, cosmetics, paint and the fragmentation of larger items. They are widely distributed throughout the natural environment with evidence of harm at multiple levels of biological organization.
The rat’s tale
Books et al. Animal Biology A charming rodent romp misses some of the creature’s most interesting and unsettling history Get full access to this article View all available purchase options and get full access to this article. References and Notes 1 E. Marris, “Rats come out of hiding as lockdowns eliminate urban trash,” National Geographic, 3 April 2020; https://www.nationalgeographic.com/animals/article/urban-rats-search-for-food-coronavirus. 2 M. Crofts, J.
Atmospheric blocking slows ocean-driven melting of Greenland’s largest glacier tongue
Editor’s summary Greenland has been experiencing accelerating glacier mass loss in recent years. McPherson et al. have found that melting of the 79 North Glacier, which discharges into the ocean, has been slowed somewhat in recent years. Observations at the site of ice discharge show that from 2018 to 2021, water temperatures below the ice tongue cooled.
Hot and cold Earth through time
The current extent of the Arctic ice cap is shown. The polar regions were ice-free for much of Earth’s history. What was Earth’s temperature tens to hundreds of millions of years ago? The planet has gone through different periods, some with extensive polar ice caps and others being completely ice-free. Estimating past global temperature is important for understanding the history of life on Earth, for predicting future climate, and more broadly, to inform the search for other habitable planets.
Early education’s long-term benefits-Response
Information & Authors Information Published In Science Volume 385 | Issue 6715 20 September 2024 Copyright Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Article versions Submission history Published in print: 20 September 2024 Permissions Request permissions for this article.
MAYEX is an old long noncoding RNA recruited for X chromosome dosage compensation in a reptile
Editor’s summary Dosage compensation of sex chromosomes can be mediated either by overexpressing genes in the heterogametic sex or by silencing one copy in the homogametic. These processes are complex but are usually mediated by long noncoding RNAs (lncRNAs); however, they are difficult to study because they are not often shared broadly across species. Tenorio et al. examined the green anole and found that genes on the X chromosome are overexpressed in males.
High-fidelity teleportation of a logical qubit using transversal gates and lattice surgery
Editor’s summary Quantum entanglement and the teleportation of a quantum state across the processor are key ingredients in quantum computing. The fragility of the quantum states, however, requires error correction codes to ensure their faithful processing. Using a trapped-ion platform consisting of up to 30 trapped ions, the Quantinuum H2 quantum processor, Ryan-Anderson et al. demonstrate the fault-tolerant teleportation of quantum states.
Model citizens
AAAS login provides access to Science for AAAS Members, and access to other journals in the Science family to users who have purchased individual subscriptions. Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
Squeezing the quantum noise of a gravitational-wave detector below the standard quantum limit
Editor’s summary Gravitational wave detectors use kilometers-long interferometers to measure tiny expansions and contractions of spacetime. The precision of those measurements is limited due to quantum mechanics. Theoretically, that quantum limit could be surpassed by using squeezed states of light, and a suitable filter cavity could extend the advantage over a wide frequency range (see the Perspective by Aso). Jia et al.
Large library docking identifies positive allosteric modulators of the calcium-sensing receptor
Editor’s summary Calcium levels in the body are sensed by a G protein–coupled receptor that mediates homeostasis through control of hormone secretion. Allosteric modulator drugs that influence the calcium-sensing receptor’s activation or inactivation are used to treat secondary hyperparathyroidism in patients with chronic kidney disease, but adverse effects related to hypocalcemia are a serious issue. Using computational docking, Liu et al.
Early education’s long-term benefits
Get full access to this article View all available purchase options and get full access to this article. References and Notes 1 J. L. García, J. J. Heckman, Annu. Rev. Econ. 15, 349 (2023). 2 P. Kline, C. R. Walters, Quart. J. Econ. 131, 1795 (2016). 3 A. Feller, T. Grindal, L. Miratrix, L. C. Page, Ann. Appl. Stat. 10, 1245 (2016). 4 M. J. Bailey, S. Sun, B. Timpe, Am. Econ. Rev. 111, 3963 (2021). 5 A. Barr, C. R. Gibbs, J. Polit. Econ. 130, 3253 (2022). 6 E. Garces, D. Thomas, J. Currie, Am. Econ. Rev. 92, 35 (2002). 7 8 W. R. Dougan, J. L.
KRAS takes the road to destruction
Perspective Cancer A single small molecule degrades numerous KRAS variants involved in cancer Adrienne D. Cox and Channing J. Der Authors Info & Affiliations Abstract Mutations in the KRAS (Kirsten rat sarcoma viral oncogene homolog) gene are a major driver of cancer development and metastatic growth.
Our perennial rodent companions
Introduction to Special Issue Caroline Ash, Bianca Lopez, [...] , Sacha Vignieri, and Brad Wible+1 authors fewerAuthors Info & Affiliations Brown rats (Rattus norvegicus) live essentially everywhere that humans reside. Surprisingly little is known about their original habitat or ecology and evolution in the wild. PHOTO: CHARLIE HAMILTON JAMES Thanks to humans, house mice and brown and black rats are now some of the few species on the planet that can be found almost everywhere.
Who cares about lab rodents?
Policy Forum Animal Research Humanities and social sciences help advance “cultures of care” around laboratory animal science and welfare Gail Davies, Robert G. W. Kirk , [...] , Beth Greenhough, Pru Hobson-West, [...] , Dmitriy Myelnikov, and Emma Roe+3 authors +1 authors fewerAuthors Info & Affiliations Abstract Rodents are widely seen as a commensal pest species and an unwelcome addition to human society.
Radical-mediated click-clip reactions
Editor’s summary Click chemistry refers to a growing class of coupling reactions that proceed rapidly to high conversion under mild conditions while avoiding competing pathways and generating relatively little waste. The main drawback to this technique is that the strong driving force underlying these favorable properties tends to prevent reversibility. Zhao et al. report an oxidative coupling between amines and phenothiazines that manifests click-like efficiency at room temperature.
The complex affective and cognitive capacities of rats
Abstract For several decades, although studies of rat physiology and behavior have abounded, research on rat emotions has been limited in scope to fear, anxiety, and pain. Converging evidence for the capacity of many species to share others’ affective states has emerged, sparking interest in the empathic capacities of rats.
Pushing the boundaries of gravitational wave detection
Perspective Astrophysics Broadband reduction of quantum noise should accelerate discovery Abstract The detection of ripples in spacetime, which are known as gravitational waves (GWs), has emerged as a critical frontier in modern astrophysics. Indeed, kilometer-scale detectors, such as the Laser Interferometer Gravitational-Wave Observatory (LIGO), have provided insights into energetic astronomical events, including the mergers of black holes and neutron stars.
Targeting cancer with small-molecule pan-KRAS degraders
Editor’s summary Kirsten rat sarcoma virus (KRAS) is a frequently mutated oncogene in human cancer. Targeting KRAS function is a high priority for cancer drug development, and in recent years, drugs that inhibit the KRAS glycine 12–to–cysteine (G12C) mutation have been developed. However, additional KRAS tumor mutations occur with high prevalence, and there are currently no drugs available to inhibit them. Popow et al.
A decarbonylative approach to alkylnickel intermediates and C(sp3)-C(sp3) bond formation
Editor’s summary The abundance of both natural and synthetic carboxylic acids has motivated multiple recent breakthroughs in decarboxylative methods for cross-coupling reactions. In other words, some combination of activating reagents and catalysts slice off carbon dioxide (CO2), leaving behind the alkyl component to form a carbon-carbon bond with a coupling partner. However, these approaches rely on radical mechanisms that can be unselective. Huang et al.
Origin and fate of the pseudogap in the doped Hubbard model
Editor’s summary Despite its simplicity, the Hubbard model may be capable of describing some instances of strongly correlated matter. However, this remains difficult to solve numerically; connecting the results at zero and finite temperatures is particularly tricky. Simkovic et al. used diagrammatic Monte Carlo calculations to examine the appearance of the pseudogap phase in the doped Hubbard model at finite temperatures.
Germline mutations in a G protein identify signaling cross-talk in T cells
Information & Authors Information Published In Science Volume 385 | Issue 6715 20 September 2024 Copyright Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an article distributed under the terms of the Science Journals Default License.
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway - Nature Immunology
|
Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01691-y, published online 3 January 2024. In the version of the article initially published, Buket Dalgıç (Department of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey) was mistakenly omitted from the author list and has now been added in the HTML and PDF versions of the article. About this article Park, A.Y., Leney-Greene, M., Lynberg, M. et al.
By Ann Park, Justin Q. Gabrielski, Hyoungjun Ham, Jean Michel Chanchu, Aaron R. Morawski, Aiman J. Faruqi, Samuel D. Chauvin, Holden T Maecker, Saban Tekin, Altan Kara, Odile Filhol, Mark Davis, Erika L. Pearce, Oliver Daumke, Caner Aytekin, V. Koneti Rao, Sule Haskologlu, Safa Baris, Helen Su, Satoshi KUBO
|
Nature
Verified
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway - Nature Immunology
|
Abstract Preserving cells in a functional, non-senescent state is a major goal for extending human healthspans. Model organisms reveal that longevity and senescence are genetically controlled, but how genes control longevity in different mammalian tissues is unknown.
By Ann Park, Aiman J. Faruqi, Samuel D. Chauvin, Holden T Maecker, Altan Kara, Odile Filhol, Mark Davis, Erika L. Pearce, Oliver Daumke, Caner Aytekin, V. Koneti Rao, Sule Haskologlu, Safa Baris, Helen Su, Justin Q. Gabrielski, Hyoungjun Ham, Jean Michel Chanchu, Aaron R. Morawski, Saban Tekin, Satoshi KUBO
|
Nature
Verified
The global tree restoration potential
The potential for global forest cover The restoration of forested land at a global scale could help capture atmospheric carbon and mitigate climate change. Bastin et al. used direct measurements of forest cover to generate a model of forest restoration potential across the globe (see the Perspective by Chazdon and Brancalion). Their spatially explicit maps show how much additional tree cover could exist outside of existing forests and agricultural and urban land.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Hyoungjun
Contact Hyoungjun, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack