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Hyun Seo Yu

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Articles

Integrated Chromatin Accessibility and Transcriptomic Profiles Across Replicative Senescence Stages in Human Colonic Fibroblasts

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By Young-Kyoung Lee, Min Sung, Dong Jun Kim, June Seok Heo, Seong Hwan Park, Jin Ho Bae, Wonbeen Kang, Afzal Rana Aqeel, Hyoung Rae Lee, Ji Hee Cha, Hyun Seo Yu
| Nature Verified
Abstract Cellular senescence is accompanied by widespread chromatin and transcriptional remodeling, but datasets that capture these changes across intermediate stages of replicative senescence remain limited. Here, we present an integrated bulk RNA-seq and ATAC-seq resource generated from primary human colonic fibroblasts spanning three replicative states: early-passage young cells, intermediate pre-senescent cells, and late-passage senescent cells.
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