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Hyungkyung Shin on Muck Rack

Hyungkyung Shin

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Articles

Rewiring KRAS-driven cancers through the ubiquitin–proteasome system: therapeutic opportunities with a focus on deubiquitinase

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By Yeonjoo Lee, Seung Seo, Ji Yang, Yeon Jung Kim, Young-Mee Kim, Eun Joo Song, SuA Hwang, Hyungkyung Shin, Kyeongeun Choi, HyoKyoung Kim
| Nature Verified
Abstract KRAS is one of the most frequently mutated oncogenes in human cancers and plays a central role in regulating signaling pathways that control cell proliferation, survival and metabolism. Recent advances in allele-specific inhibitors, particularly those targeting KRASG12C, have demonstrated that direct pharmacological inhibition of KRAS is clinically feasible.
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