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Hyunsoo Rho

As seen in: Nature, MDPI, Cell Metabolism
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Articles

p21-activated kinase 4 drives hepatic stellate cell activation and liver fibrosis through the phosphorylation of YAP at T428

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By Gil-Hwan Kim, Hyunsoo Rho, Chang Hun Lee, You-Jung Hong, Yongdo Park, Hwang Chan Yu, Mi-Young Song, Hye Jin Jo, Eun Joo Kang, Ri Han, Song Yu, Ekihiro Seki, Yoonji Lee, Sangkyu Lee, Eun Ju Bae, Byung-Hyun Park, Chang Han
| Nature Verified
Abstract Understanding the molecular mechanisms that govern hepatic stellate cell (HSC) fate is essential for developing effective antifibrotic therapies. Yes-associated protein (YAP) plays a pivotal role in organ fibrogenesis and HSC activation, but its upstream regulatory signals in liver fibrosis remain largely unknown. Here, we demonstrate the role of p21-activated kinase 4 (PAK4), an emerging therapeutic target, in the activating phosphorylation of YAP and subsequent HSC activation.
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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

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By Alexander R. Terry, Veronique Nogueira, Hyunsoo Rho, Gopalakrishnan Ramakrishnan
| Cell Metabolism Verified
• None Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. : • None Cloning of a rat adipocyte membrane-protein implicated in binding or transport of long-chain fatty-acids that is induced during preadipocyte differentiation – homology with human CD36. : • None Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
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JMSE | Free Full-Text | Oncholaimus tripapillatus sp. nov., a New Free-Living Marine Nematode of the Genus Oncholaimus Dujardin, 1845 (Nematoda: Enoplida: Oncholaimidae) from the Subtidal Sediment of Dokdo Island, East Sea, Korea, with a New Record of O.

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By Hyojin Lee, Heegab Lee, Hyunsoo Rho
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
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