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I. D. Barr on Muck Rack

I. D. Barr

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Articles

Multiomic analysis identifies glutaminolysis-dependent metabolic enhancement of immune memory utilised for vaccine development

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By S. Clare, D. V. Griffiths, O. Knight, C. B. Connor, A. K. Denton, H. Daniel Peck, P. Lyons, I. D. Barr, E. F. McKinney, J. M. Sowerby, P. Kotagiri, I. Cuthbertson, K. Harcourt, P. Pereyra Gerber, I. Pshenichnaya, G. A. Stoll, C. Matara, C. Keel, G. Manferrari, T. Birkle, P. Naydenova, Y. Modis, G. Dougan, N. J. Matheson, K. G. C. Smith
| Nature Verified
Abstract Vaccines work by inducing an immunological memory response to protect against infection or disease. More effective vaccines are required to improve protection of high-risk groups such as the elderly. Here we screen transcriptional signatures of T cell memory against repurposable drug signatures, identifying a subclass of lysine deacetylase inhibitors (KDACi) capable of promoting a memory precursor phenotype in primary T cells.
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