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Ian de de Ridder

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Articles

Cancer-Associated BCL-2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

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By Jonas Aufdermauer, Ian de de Ridder, Mahjoobeh Ehsani
| Wiley Online Library Verified
1 Introduction The B-cell lymphoma 2 (BCL-2) family of proteins controls mitochondrial outer membrane permeabilization (MOMP), the process that determines the onset of apoptosis. MOMP enables the release of cytochrome c and SMAC/Diablo from the mitochondrial intermembrane space into the cytosol and the subsequent activation of caspases, leading to apoptosis [1].
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