Chronic atopic dermatitis (AD) has an alarming propensity to generate psychiatric comorbidities, with patients with chronic AD incurring an approximately 7 times higher risk of developing major depressive disorder (MDD).1 Today, the link between AD and neuropsychiatric disorders, particularly depression, is well established.2,3 However, the mechanisms speculated so far have primarily fixated on systemic inflammation, sleep disturbance, stress responses mediated by the...