IBD Leuven on Muck Rack

IBD Leuven

As seen in: Oxford Academic
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The Impact of PAD4-dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn’s Disease

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By KU Leuven, Hospitals Gasthuisberg Leuven, De Hertogh, IBD Leuven
| Oxford Academic
During early phases of inflammation, activated neutrophils extrude neutrophil extracellular traps (NETs) in a PAD4-dependent manner, aggravating tissue injury and remodelling. In this study, we investigated the potential pro-fibrotic properties and signalling of NETs in Crohn’s disease (CD). NETs and activated fibroblasts were labelled on resected ileum from CD patients by multiplex immunofluorescence staining.
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