Ibtissem Ben Brahim on Muck Rack

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Hypoxia-mediated fine-tuning of the TLR7/9-triggered human PDC-derived IFN-α response is mediated by combined cellular and soluble IFN-regulators

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By Felix Herrmann, Alexander Lenkewitz, Ibtissem Ben Brahim, Noor-A-Kasida Islam
| biorxiv.org
Abstract Hypoxia occurs in settings where stringent control of inflammation is mandatory to avoid tissue damage. Here, we analyzed how hypoxia-induced mediators alter recognition of pathogen-derived molecular patterns (PAMPs). The most relevant finding was that hypoxia selectively targets IFN-α induced upon stimulation with nucleic acid-sensing Toll-like receptors (TLR7/8 and -9) in PBMC. Notably, IFN-α secretion was reduced, but IFN-α producing capacity preserved.
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