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ICAN Omics

As seen in: Frontiers
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Articles

Frontiers | Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medullary collecting duct cells, independently of nephrocystin-1 and nephrocystin-4

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By Institut Necker Enfants-Malades, Anne-Marie Tassin, Francesca Di Sole, ICAN Omics
| Frontiers
Introduction Nephronophthisis (NPH) is an autosomal recessive tubulo-interstitial nephropathy that accounts for up to 15% of end stage kidney disease (ESKD) in children (Hamiwka et al., 2008; Salomon et al., 2009). The juvenile form is the most prevalent (48%) and progresses to ESKD before the age of 15 (Hildebrandt et al., 2009; Petzold et al., 2023).
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