Ichcha Manipur on Muck Rack

Ichcha Manipur

As seen in: Nature, The American Journal of Human Genetics
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Articles

CoPheScan: phenome-wide association studies accounting for linkage disequilibrium - Nature Communications

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By Ichcha Manipur, Guillermo Reales, Myung Kyun Shin
| Nature Verified
Abstract Phenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants which impact a specific protein, this can help identify additional therapeutic indications or on-target side effects of intervening on that protein. However, PheWAS is restricted by an inability to distinguish confounding due to linkage disequilibrium (LD) from true pleiotropy.
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CoPheScan: phenome-wide association studies accounting for linkage disequilibrium

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By Ichcha Manipur, Guillermo Reales, Jae Hoon Sul, Myung Kyun Shin
| biorxiv.org
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Benchmark data and software for assessing genome-wide CRISPR-Cas9 screening pipelines

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By Raffaele Iannuzzi, Clare Pacini, Fiona M Behan, Ichcha Manipur
| biorxiv.org
Confirmatory Results doi: https://doi.org/10.1101/2022.09.23.509258 Abstract Genome-wide recessive genetic screens using lentiviral CRISPR-guide RNA libraries are widely performed in mammalian cells to functionally characterise individual genes and for the discovery of new anti-cancer therapeutic targets.
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