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Ida L Barlow

As seen in: BioRxiv, eLife
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Articles

High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models

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By Thomas O'Brien, Ida L Barlow, Luigi Feriani, Andre Brown
| eLife
eLife Assessment This important study provides proof of principle that C. elegans models can be used to accelerate the discovery of candidate treatments for human Mendelian diseases by detailed high-throughput phenotyping of strains harboring mutations in orthologs of human disease genes. The data are compelling and support an approach that enables the potential rapid repurposing of FDA-approved drugs to treat rare diseases for which there are currently no effective treatments.
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Systematic creation and phenotyping of Mendelian disease models in C. elegens: towards large-scale drug repurposing

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By Thomas O'Brien, Ida L Barlow, Luigi Feriani, Andre Brown
| BioRxiv
Abstract There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug development. In the absence of a validated drug target, phenotypic screening in model organisms provides a route for identifying candidate treatments.
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The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation

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By Ida L Barlow, Eirinn Mackay, Emily Wheater, Aimee Goel
| eLife
The following is the authors’ response to the original reviews. We thank the reviewers for their comments. We have now addressed all the comments in a revised version of the manuscript, which we believe has strengthened our paper. Thank you for pointing us to this reference. Van der Linden et al. demonstrated that the C. elegans homolog of Sik3 (KIN-29) regulates satiety quiescence, in which worms stop moving following feeding on high quality food.
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