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Idha Kurtsdotter

As seen in: BioRxiv
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Articles

SOX21 Suppresses Glioblastoma Growth by Repressing AP-1 Activity

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By Jonas Muhr, Eltjona Rrapaj, Juan Yuan, Idha Kurtsdotter
| BioRxiv
Abstract Background Treatment-resistant glioblastoma stem cells (GSCs) drive glioblastoma (GBM) growth and recurrence. Thus, targeting the molecular machinery that sustains GSCs in an undifferentiated and self-renewing state is a promising therapeutic strategy. The transcription factor SOX21 effectively suppresses the tumorigenic capacity of GSCs. However, the mechanism by which SOX21 impedes GSC features is unknown.
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SOX21 suppresses GBM growth by repressing AP-1 regulated target genes

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By Jonas Muhr, Eltjona Rrapaj, Juan Yuan, Idha Kurtsdotter
| BioRxiv
Abstract Resistance of glioblastoma stem cells (GSCs) to standard treatments is a major cause of glioblastoma (GBM) recurrence. This study examines the potential of the transcription factor SOX21 to inhibit GSC properties and combat GBM progression. Results show that increasing SOX21 levels in primary GSCs induces an anti-tumorigenic gene expression profile, which is substantiated by a significant correlation between high SOX21 expression and improved survival rates of GBM patients.
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SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells

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By Idha Kurtsdotter, Danijal Topcic, Alexandra Karlén, Bhumica Singla
| cancerres.aacrjournals.org
Tumor and Stem Cell Biology SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells Idha Kurtsdotter, Danijal Topcic, Alexandra Karlén, Bhumica Singla, Daniel W. Hagey, Maria Bergsland, Peter Siesjö, Monica Nistér, Joseph W. Carlson, Veronique Lefebvre, Oscar Persson, Johan Holmberg and Jonas Muhr
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