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Ielyzaveta Slarve on Muck Rack

Ielyzaveta Slarve

As seen in: Nature
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Articles

PTEN-AKT2 regulates mixed lineage liver cancer development and sensitizes cancer cells to TGFβ treatment

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By Qi Tang, Jingyu Chen, Ni Zeng, Yiwei Gu Verified, Lina He, Shunan Hu, Zifei Xu, Guo Zhang, Phillip Nguyen, Phillip Nguyễn, Mario Gomar Alba, Ajay N Bharadwaj, Jihyeon Lee, Simion Kreimer, Jian Xu, Baoan Ji, Shelly C. Lu, Jennifer Van Eyk, Shefali Chopra, Gary Kanel, Liyun Yuan, Bangyan Stiles, Ielyzaveta Slarve, Diala Alhousari, Brittney Hua
| Nature Verified
Abstract Primary liver cancers, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), arise from the neoplastic transformation of hepatocytes and cholangiocytes, respectively. Loss or downregulation of PTEN, a tumor suppressor negatively regulating the PI3K/AKT pathway, is frequently observed in CCA and HCC. Notably, PTEN mutations are observed at nearly twice the frequency in combined CCA-HCC tumors than either HCC or CCA alone.
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