Ifigeneia Akrani on Muck Rack

Ifigeneia Akrani

As seen in: MDPI
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Articles

Discovery and Characterization of Uracil Derivatives Targeting the Set-and-Ring Domain of UHRF1

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By Ifigeneia Akrani, Danai Driva, Efstratios Tsakalidis, Nandini Mozumdar
| dx.doi.org
Introduction Click to copy section linkSection link copied! Epigenetics is currently recognized as a particularly exciting scientific field at the interface between core biology and therapeutics. The increasing medical interest in epigenetic mechanisms and their implications in human health arise from collective experimental evidence indicating their multisided involvement in fundamental biological processes such as cellular growth, differentiation, immune responses, and malignant transformation.
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Discovery of Novel Inhibitors against ALS-Related SOD1(A4V) Aggregation through the Screening of a Chemical Library Using Differential Scanning Fluorimetry (DSF)

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By Maria Giannakou, Ifigeneia Akrani, Vassilios Myrianthopoulos, Angeliki Tsoka
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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High-resolution structures of the UapA purine transporter reveal unprecedented aspects of the elevator-type transport mechanism.

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By Ifigeneia Akrani, George Broutzakis, Yiannis Pyrris, Alexander Neuhaus
| biorxiv.org
Abstract UapA is an extensively studied elevator-type purine transporter from the model fungus Aspergillus nidulans. Determination of a 3.6 A inward-facing crystal structure lacking the cytoplasmic N-and C-tails, molecular dynamics (MD), and functional studies have led to speculative models of its transport mechanism and determination of substrate specificity.
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