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New approach methods to improve human health risk assessment of thyroid hormone system disruption-a PARC project

|
By Cañas-Portilla AI, Haigis AC, Iglesias-Hernandez P, Morthorst JE
| ncbi.nlm.nih.gov
Full text links Cite Display options Display options Format AbstractPubMedPMID Abstract Current test strategies to identify thyroid hormone (TH) system disruptors are inadequate for conducting robust chemical risk assessment required for regulation. The tests rely heavily on histopathological changes in rodent thyroid glands or measuring changes in systemic TH levels, but they lack specific new approach methodologies (NAMs) that can adequately detect TH-mediated effects.
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