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Articles

Circulating plasma cells (polyclonal and monoclonal) as markers of an aggressive multiple myeloma phenotype

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By Ilaria Vigliotta, Vincenza Solli, Silvia Armuzzi, Gaia Mazzocchetti, Enrica Borsi, Marina Martello, Andrea Poletti, Katia Mancuso, Marco Talarico, Michele Cavo, Elena Zamagni, Carolina Terragna, Alessia Varacalli, Barbara Taurisano, Ignazia Pistis, Viola Meixian Vuong, Alessia Croce, Michele Puppi
| Nature Verified
Abstract Multiple myeloma (MM) is characterized by the proliferation of malignant plasma cells (PCs) in the bone marrow (BM). The pathogenesis of MM is complex and multifactorial, with significant heterogeneity among patients, making risk stratification and disease monitoring difficult. In this study, the potential role of circulating plasma cells (CPCs), including polyclonal CPCs, as innovative biomarkers, was evaluated in 108 MM patients.
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