Igor D Luzhansky

Abstract Oxaliplatin triggered chemotherapy induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cancer treatment which limits the efficacy of chemotherapy and negatively impacts patients quality of life dramatically. To better understand the mechanisms of OIPN and screen for potential therapeutic targets, it is critical to have reliable in vitro assays that effectively mirror the neuropathy in vivo.

1. Introduction Peripheral nerve injuries are common, often greatly reduce quality of life, and are economically costly.1 In a complete transection injury where the stumps cannot be directly reattached, the gap can be spanned with donor nerve grafts or artificial alternatives such as nerve guidance conduits (NGCs). NGCs are tubes inside which the nerve ends are surgically affixed, spatially confining the regeneration process.

Metrics Downloaded 0 times History Received 15 March 2019 Accepted 20 August 2019 Published online 15 October 2019 Information © 2019 Future Medicine Ltd KeywordsAcknowledgments The authors thank the Institute of Materials Science & Engineering at Washington University for their support and participation.