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Igor I. Kuzin on Muck Rack

Igor I. Kuzin

As seen in: The Journal of Immunology
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Articles

Increased numbers of CD23+CD21hi Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes

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By Stephen Kates, Steven Bernstein, Igor I. Kuzin, Yawen Ju, Longze Zhang, Homaira Rahimi, Wojciech Wojciechowski, Richard Burack, Edward M. Schwarz, Andrea Bottaro
| Allergy - European Journal of Allergy and Clinical Immunology Verified
A unique population of CD23+ CD21highB cells in inflamed nodes (Bin) has been shown to accumulate in lymph nodes (LNs) draining inflamed joints of TNF-transgenic (TNF-tg) mice. Bin cells contribute to arthritis flare in mice by distorting node architecture and hampering lymphatic flow, but their existence in human inflamed LNs has not yet been described.
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Stromal cells from inflamed lymph nodes modulate B cell surface CD23 expression

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By Andrea Bottaro, Igor I. Kuzin, Steven Bernstein, Etty Sims, Yekaterina Koshkareva
| The Journal of Immunology Verified
CD23 is a trans-membrane protein belonging to the C-type lectin family, widely expressed in the immune system. Originally identified as the low-affinity receptor for IgE, CD23 was later shown to also bind CD21, MHCII and various integrins, and to have pleiotropic roles, including modulation of cell proliferation, differentiation, Ig and cytokine secretion.
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Accumulation of CD23+ CD21-high Bin-like cells in human reactive and rheumatoid arthritis lymph nodes

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By Andrea Bottaro, Igor I. Kuzin, Stephen Kates, Homaira Rahimi, Yawen Wu
| The Journal of Immunology Verified
We have previously described a unique population of CD23+ CD21-high B cells in inflamed nodes (Bin) which accumulate in lymph nodes (LN) draining inflamed joints of TNF-transgenic (TNF-tg) mice, and contribute to arthritis flare by distorting node architecture and hampering lymphatic flow. The existence of Bin-like cells in human inflamed LN is yet unknown.
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