Igor Yu. Dolmatov

Abstract Eupentacta fraudatrix is the only species of sea cucumbers for which transdifferentiation has been described. This type of cell type switching occurs during gut regeneration after evisceration, which makes this species a scientifically valuable model for studying regeneration mechanisms. Moreover, chromosome-level genomes for the family Sclerodactylidae have not been available until now.

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Igor Yu. Dolmatov * and Vladimir A. Nizhnichenko A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Palchevsky 17, 690041 Vladivostok, Russia * Author to whom correspondence should be addressed. Mar.

The mechanical properties of structures containing fibrillar collagens largely depend on cross-links, which are formed due to the activity of transglutaminase-2 and Lox. For example, the stiffness of connective tissue, observed in case of various carcinomas and other diseases, is probably a result of increased activity of Lox [ 126 – 128 ]. On the other hand, a reduction in Lox expression decreases the stiffness of ECM and prevents fibrosis [ 129 ].