Iju Yeh on Muck Rack

Iju Yeh

As seen in: Frontiers
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Articles

Methylation of the epigenetic JMJD2D protein by SET7/9 promotes prostate tumorigenesis

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By Parthasarathy Seshacharyulu, Shumeng Liu, Iju Yeh
| Frontiers
Introduction Tri- and dimethylation of histone H3 on lysine K9 (H3K9me3/2) are prominent epigenetic marks associated with transcriptional repression (1), and changes in these posttranslational modifications are commonly involved in the development of cancer (2). The degree of H3K9 methylation is determined by the opposing actions of histone methyltransferases and demethylases, whose expression or activity is often altered in tumors (3, 4).
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