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Abstract Our knowledge of which bone marrow cells affect red cell production is still incomplete. To explore the role of osteocytes in the process we performed bulk RNAseq of osteocytes isolated from control and phlebotomized mice. The top-upregulated gene following phlebotomy was Fam132b, erythroferrone (Erfe). Erfe expression in osteocytes was also upregulated after erythropoietin (EPO) treatment and hypoxia in vitro.
An immunohistochemical study of lymphatic elements in the human brain Edited by Lawrence Steinman, Stanford University School of Medicine, Stanford, CA, and approved November 30, 2020 (received for review February 21, 2020) Significance The connection between brain and peripheral lymphatics has been studied for 250 y, mainly in animals. Specific markers for lymphatic endothelial cells (LECs) were discovered about a decade ago.
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