Ildikó Vargáné Tóth

Involvement of multiple organs is possible, most commonly skin and connective tissue, lung, or blood vessels, and classical features include polychondritis, neutrophilic dermatosis, or vasculitis [1, 2]. Several hot-spot mutations of UBA1 have been described, most prominently involving methionine 41. Treatment with high-dose glucocorticoids is effective, and steroid-sparing approaches mainly include hypomethylating agents, Janus kinase (JAK) inhibitors, or IL-1 or IL-6 directed approaches [3].

1 Introduction The ongoing COVID-19 pandemic is causing an unprecedented global health crisis, in which not only demographic and socioeconomic factors, underlying health conditions such as obesity and diabetes, or gender affects disease severity and mortality [1] but also genetic predisposition contributes to the development of severe COVID-19 [2].

A new methodology for determination of sulfonamides (sulfaquinoxaline, sulfathiazole, and sulfadimethoxine) in water samples was developed by coupling an automated multi-pumping flow system (MPFS) with a liquid waveguide capillary cell (LWCC; pathlength, 100 cm) and a spectrophotometric detector.