Ilgın Eser Kotan on Muck Rack

Ilgın Eser Kotan

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Articles

SRP orchestrates protein biogenesis beyond initial ER membrane targeting

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By Sabrina Sartori, Rudra Bose, Bernd Bukau, Günter Kramer, Ilgın Eser Kotan
| Nature Verified
Abstract The Signal Recognition Particle (SRP) targets nascent proteins to the Sec61 translocon for import into the endoplasmic reticulum (ER). However, its range of substrates, point of engagement during targeting, and hence full biological impact remain unclear. Here, we examined SRP interactions with the nascent proteome of S. cerevisiae during translation and membrane targeting.
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