Ilmini De Silva on Muck Rack

Ilmini De Silva

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Articles

NK cell dysregulation may potentiate cardiovascular disease in adolescents with perinatally acquired HIV on antiretroviral therapy

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By Mario Alles, Manuja Gunasena, Victor Musiime, Cissy Kityo, Brian Richardson, Will Mulhern, Shan Sun, Grace A McComsey, Thorsten Demberg, Cheryl M Cameron, Mark Cameron, Nicholas Funderburg, Sahera Dirajlal-Fargo, Aaren Kettelhut, Kate Ailstock, Banumathi Tamilselvan, Michael Rubsamen, Ilmini De Silva, Dilani Somasiri, Dhanuja Kasturiratna, Namal P. M. Liyanage
| Nature Verified
Abstract Perinatally acquired HIV (PHIV) and antiretroviral therapy (ART) can alter innate immune cells, (monocytes and natural killer [NK] cells) which are important in the pathogenesis of cardiovascular disease (CVD). We compare cardiovascular biomarkers and immune signatures between adolescents with PHIV (APHIV) on suppressive ART and HIV-unexposed, adolescents without HIV in Uganda. Carotid intima-media thickness (IMT) is increased in APHIV, suggesting a higher CVD risk.
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