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Health-Related Quality of Life in Disease-Modifying Antirheumatic Drug-Treated Adults With Juvenile Idiopathic Arthritis Compared to Rheumatoid Arthritis and the General Population | The Journal of Rheumatology
Key Indexing Terms: health-related quality of life juvenile idiopathic arthritis rheumatoid arthritis SF-6D SF-36 Juvenile idiopathic arthritis (JIA) is a chronic inflammatory joint disease defined by an onset before the age of 16.1,2 Longitudinal studies indicate that JIA persists into adulthood in approximately half of the patient population,3-8 either as persistently active disease or as disease in remission on immunosuppressive medication.
Health-related Quality of Life in DMARD-treated adults with Juvenile Idiopathic Arthritis Compared to Rheumatoid Arthritis and the General Population
Health-related Quality of Life in DMARD-treated adults with Juvenile Idiopathic Arthritis Compared to Rheumatoid Arthritis and the General Population Imane Bardan, Till Uhlig, Joe Sexton, Tore Kristian Kvien, Gunnstein Bakland, Pawel Mielnik, Yi Hu, Øyvind Molberg, Anna-Birgitte Aga, Eirik Klami Kristianslund The Journal of Rheumatology Sep 2025, jrheum.2025-0384; DOI: 10.3899/jrheum.2025-0384
Treatment Response to Tumor Necrosis Factor Inhibitors and Methotrexate Monotherapy in Adults With Juvenile Idiopathic Arthritis: Data From NOR-DMARD
DISCUSSION The current study is among the largest exploring treatment effects of TNFi and the first, that we know of, to explore MTX monotherapy in adult patients with JIA. We found that both TNFi ± comedication and MTX monotherapy are effective in treating disease activity in adult patients with JIA, with similar treatment effects to those in adult patients with RA. Weighted Kaplan-Meier survival analyses showed equal drug survival of TNFi and MTX in JIA and RA.
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