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Immaculeta Osuji on Muck Rack

Immaculeta Osuji

As seen in: BioRxiv
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Articles

Pathophysiology of hypereosinophilia-associated heart disease

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By Usman Sunusi, Benjamin Ziegelmeyer, Immaculeta Osuji, Mario Medvedovic
| BioRxiv
Abstract Background: Cardiac complications in patients with hypereosinophilia cause significant morbidity and mortality. However, mechanisms of how eosinophilic inflammation causes heart damage are poorly understood. Methods: We developed a model of hypereosinophilia-associated heart disease by challenging hypereosinophilic mice with peptide from the cardiac myosin heavy chain.
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Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.

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By Ramesh Kudira, Zi Yang, Rebekah Karns, Immaculeta Osuji
| BioRxiv
Abstract Fibrosing cholangiopathies, including biliary atresia and primary sclerosing cholangitis, involve immune-mediated bile duct epithelial injury and hepatic bile acid (BA) retention (cholestasis). Regulatory T-cells (Tregs) can prevent auto-reactive lymphocyte activation, yet the effects of BA on this CD4 lymphocyte subset are unknown. Gene regulatory networks for hepatic CD4 lymphocytes in a murine cholestasis model revealed Tregs are polarized to Th17 during cholestasis.
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