Inari Kursula

Conflict of interest The authors declare no conflict of interest. References 1 & (2009) Actin, a central player in cell shape and movement. Science 326, 1208–1212. 2 (2016) Actin and actin-binding proteins. Cold Spring Harb Perspect Biol 8, a018226. 3 & (2003) Cellular motility driven by assembly and disassembly of actin filaments. Cell 112, 453–465. 4, , , & (2004) Regulating filopodial dynamics through actin-depolymerizing factor/cofilin. Anat Sci Int 79, 173–183.

Abstract Malaria is caused by protozoan parasites, Plasmodium spp., that belong to the phylum Apicomplexa. The life cycle of these parasites depends on two different hosts; the definitive host, or vector, is a mosquito, and the intermediate host is a vertebrate, such as human. Malaria parasites use a unique form of substrate-dependent motility for host cell invasion and egress, which is dependent on an actomyosin motor complex called the glideosome.

Loading metrics Open Access Peer-reviewed Research Article Citation: Khorsand F, Haug BE, Kursula I, Reuter N, Brenk R (2024) Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding. PLoS ONE 19(6): e0294827.