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Inbar Bahat on Muck Rack

Inbar Bahat

As seen in: Nature
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Articles

A protein–small molecule conjugate as a bispecific inhibitor of proteases implicated in cancer metastasis

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By Andreas Baumann, Aubry K. Miller, Niv Papo, Inbar Bahat, Yuval Pinkert, Eyal Arbely
| Nature Verified
Abstract Matrix metalloproteinase-9 (MMP-9) and kallikrein 6 (KLK6) are key extracellular proteases implicated in metastatic progression. In colorectal and pancreatic cancers, their overexpression correlates with aggressive disease and poor prognosis, making them attractive therapeutic targets. While monospecific inhibition of either protease shows limited efficacy, simultaneous dual inhibition has not yet been explored as a strategy to block metastasis.
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