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Synthesis, Physicochemical Characteristics, Self-Assembly and Encapsulation Ability of per-Ethylene-Glycol-Functionalized Resorcin[4]Arenes and Their Molecular Capsules: On the Road to Liquid Capsules
1 Introduction Supramolecular chemistry uses, among others, self-assembly to create new molecular systems that have myriad applications in different fields [1, 2]. Macrocycles are essential building blocks for the preparation of host–guest and many self-assembled supramolecular systems [3-5]. Macrocyclic arenes [6-8] have played a pivotal role in the preparation of self-assembled molecular cages and capsules [9-14].
Harnessing Pillar[5]arene Host-Guest Complexation To Improve pH Stability and Affect Enzymatic Degradation of the Anticancer Prodrug Capecitabine: A 19F NMR Study - Horin - Chemistry – A European Journal - Wiley Online Library
Abstract Cancer is a global health problem, and supramolecular chemotherapy is emerging as a novel strategy to battle the disease. Here, we first evaluated the thermodynamic and kinetic stability of the complexes formed between several water-soluble per-substituted pillar[5]arene derivatives and capecitabine (1), a widely used oral chemotherapeutic prodrug.
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