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Inbar Shapira on Muck Rack

Inbar Shapira

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N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model - Nature Communications

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By Stefano Suzzi, Tommaso Croese, Sergey Malitsky, Maxim Itkin, Anna Greka, Naomi Habib, Inbar Shapira, Sarah P. Colaiuta
| Nature Verified
Abstract Systemic immunity supports lifelong brain function. Obesity posits a chronic burden on systemic immunity. Independently, obesity was shown as a risk factor for Alzheimer’s disease (AD). Here we show that high-fat obesogenic diet accelerated recognition-memory impairment in an AD mouse model (5xFAD). In obese 5xFAD mice, hippocampal cells displayed only minor diet-related transcriptional changes, whereas the splenic immune landscape exhibited aging-like CD4+ T-cell deregulation.
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