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Inbar Yosibash on Muck Rack

Inbar Yosibash

As seen in: BioRxiv
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A Plasma Membrane Vesicle Imaging-Based Platform for Studying Membrane Fusion

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By Suman Khan, Alexandra Lichtenstein, Raviv Dharan, Inbar Yosibash
| BioRxiv
Abstract Membrane fusion is fundamental to biological processes such as fertilization and viral infection. However, studying fusion mechanisms in live cells is challenging due to their complex composition and topography. To address this, we developed a cell-free system based on giant plasma membrane vesicles (GPMVs), enabling us to study the binding and fusion of the SARS-CoV-1 Spike protein with the human ACE2 receptor in a simplified yet physiologically relevant membrane environment.
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