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Indora Tanudin

As seen in: Nature
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Targeting chondroitin synthase 1 attenuates hyperplastic arterial remodeling via gene therapy

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By Dan Liao, Rong zhao, Shuji Mizumoto, Jing Wong, Efthymios Motakis, Jing Tian, Rijan Gurung, Zenia Tiang, Edita Aliwarga, Shuhei Yamada, Matthew Ackers-Johnson, Arthur Richards, Bruno Reversade, Cho Yeow Koh, Wei Seng Chng, Indora Tanudin
| Nature Verified
Abstract Chondroitin sulfate glycosaminoglycans accumulate excessively in the extracellular matrix during pathological remodeling and exacerbate cardiovascular deterioration. Here we show that chondroitin synthase 1 (CHSY1) is the primary enzyme responsible for chondroitin sulfate synthesis, as identified through in-house single-cell RNA sequencing.
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