Inès Barthélemy
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Ambulatory electrocardiographic longitudinal monitoring in a canine model for Duchenne muscular dystrophy identifies decreased very low frequency power as a hallmark of impaired heart rate variability | Scientific Reports
Abstract Duchenne muscular dystrophy (DMD) patients exhibit a late left ventricular systolic dysfunction preceded by an occult phase, during which myocardial fibrosis progresses and some early functional impairments can be detected. These latter include electrocardiographic (ECG) and heart rate variability (HRV) abnormalities.
Spatial and Temporal Non-Uniform Changes in Left Ventricular Myocardial Strain in Dogs with Duchenne Muscular Dystrophy
4. Discussion In this longitudinal study, significant alteration in global LV systolic function (i.e., decreased FS and EF) was revealed late by conventional echocardiography in GRMD dogs, as previously reported [6,8]. The decline in LV systolic function with age reflects the natural progression of cardiomyopathy in GRMD dogs in the absence of specific treatment targeting cardiomyopathy.
Ambulatory electrocardiographic longitudinal monitoring in dystrophin-deficient dogs identifies decreased Very Low Frequency power as a hallmark of impaired Heart Rate Variability in Duchenne Muscular Dystrophy
New Results doi: https://doi.org/10.1101/2023.05.08.539882 Abstract Background: Duchenne muscular dystrophy (DMD) patients exhibit a late left ventricular systolic dysfunction preceded by an occult phase, during which myocardial fibrosis progresses and some early functional impairments can be detected. These latter include electrocardiographic (ECG) and heart rate variability (HRV) abnormalities.
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