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Ines Prlesi

As seen in: Science Magazine, BioRxiv, Cell Press
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Articles by Ines Prlesi

Cohesin guides homology search during DNA repair using loops and sister chromatid linkages

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By Federico Teloni, Zsuzsanna Takacs, Michael Mitter, Ines Prlesi
| Science Magazine Verified
Editor’s summary Cells constantly face DNA damage that, if repaired incorrectly, can lead to cancer or genetic instability. Homologous recombination, one of the most accurate repair mechanisms, requires broken DNA to find a matching sequence among billions of bases. Using a powerful method to map DNA interactions inside cells, Teloni et al. uncovered how this search is guided by the protein complex cohesin.
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Cohesin guides homology search during DNA repair via loops and sister chromatid linkages

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By Federico Teloni, Zsuzsanna Takacs, Michael Mitter, Ines Prlesi
| BioRxiv
Abstract Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequence to faithfully restore damaged DNA, yet how broken DNA ends find homologous sites in a genome containing billions of non-homologous bases remains unclear. Here, we introduce sister-pore-C, a high-resolution method for mapping intra- and trans-molecular interactions in replicated chromosomes.
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Tunneling nanotubes enable intercellular transfer in zebrafish embryos

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By Shiyu Liu, Anna Pepe, Olga Korenkova, Ines Prlesi
| BioRxiv
Abstract Tunneling nanotubes (TNTs) are thin intercellular connections facilitating the transport of diverse cargoes, ranging from ions to organelles. While TNT studies have predominantly been conducted in cell cultures, the existence of open-ended TNTs within live organisms remains unverified. Despite the observation of intercellular connections during embryonic development across various species, their functional role has not been confirmed.
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