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Inimary Toby

As seen in: The Journal of Immunology
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Articles

Biophysicochemical Motifs in T-cell Receptor Sequences Distinguish Repertoires from Tumor-Infiltrating Lymphocyte and Adjacent Healthy Tissue

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By Jared Ostmeyer, Scott Christley, Inimary Toby, Lindsay G Cowell
| cancerres.aacrjournals.org
Translational Science Jared Ostmeyer, Scott Christley, Inimary T. Toby and Lindsay G. Cowell DOI: 10.1158/0008-5472.CAN-18-2292 Published April 2019 Abstract Immune repertoire deep sequencing allows comprehensive characterization of antigen receptor–encoding genes in a lymphocyte population. We hypothesized that this method could enable a novel approach to diagnose disease by identifying antigen receptor sequence patterns associated with clinical phenotypes.
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Biophysicochemical motifs in T cell receptor sequences distinguish repertoires from tumor-infiltrating lymphocytes and adjacent healthy tissue

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By Scott Christley, Inimary Toby, Lindsay G Cowell, Jared Ostmeyer
| cancerres.aacrjournals.org
Research Article Jared Ostmeyer, Scott Christley, Inimary T Toby and Lindsay G Cowell DOI: 10.1158/0008-5472.CAN-18-2292 Abstract Immune repertoire deep sequencing allows comprehensive characterization of antigen receptor-encoding genes in a lymphocyte population. We hypothesized that this method could enable a novel approach to diagnose disease by identifying antigen receptor sequence patterns associated with clinical phenotypes.
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VDJML - tools for capturing the results of inferring immune receptor rearrangements

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By Inimary Toby, Felix Breden, Adam Buntzman, Scott Christley, Brian Corrie
| The Journal of Immunology Verified
Despite the widespread use of immune repertoire profiling, there is currently no standardized format for output files from VDJ analysis. Researchers utilize software such as IgBlast and IMGT/High V-Quest to perform VDJ analysis and infer germline rearrangements. Each of these software tools produces results in a different file format, and can identify the same result using different labels.
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