Institut Sainte Catherine on Muck Rack

Institut Sainte Catherine

As seen in: Nature, The Lancet
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Articles

Chemotherapy (doublet or triplet) plus targeted therapy by RAS status as conversion therapy in colorectal cancer patients with initially unresectable liver-only metastases. The UNICANCER PRODIGE-14 randomised clinical trial | British Journal of Cancer

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By Institut Sainte Catherine, Hopital Sud, Hôpital Robert Debré, Institut Bergonié
| Nature Verified
Abstract Background Colorectal cancer (CRC) patients have a better prognosis if metastases are resectable. Initially, unresectable liver-only metastases can be converted to resectable with chemotherapy plus a targeted therapy. We assessed which of chemotherapy doublet (2-CTx) or triplet (3-CTx), combined with targeted therapy by RAS status, would be better in this setting. Methods PRODIGE 14 was an open-label, multicenter, randomised Phase 2 trial.
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Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial

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By Cécile Le Pechoux, Gustave Roussy, Nicolas Pourel, Institut Sainte Catherine
| The Lancet Verified
Summary Background In patients with non-small-cell lung cancer (NSCLC), the use of postoperative radiotherapy (PORT) has been controversial since 1998, because of one meta-analysis showing a deleterious effect on survival in patients with pN0 and pN1, but with an unclear effect in patients with pN2 NSCLC. Because many changes have occurred in the management of patients with NSCLC, the role of three-dimensional (3D) conformal PORT warrants further investigation in patients with stage IIIAN2 NSCLC.
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