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Ioanna Metallidou on Muck Rack

Ioanna Metallidou

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Articles

Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling

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By Joyce C. M. Meiring, Ruijie Liu, Sung Ryul Choi, Adela Karhanova, Alex Moore, Ilya Grigoriev, Matteo Giono, Saishree Iyer, Samantha J. Stehbens, J. Díaz, Zdenek Lansky, Kelly E. Stecker, Michel O. Steinmetz, Stuart C. Howes, Lukas C. Kapitein, Anna Akhmanova, Varsha Mahapatra, Molly S. C. Gravett, Daan Morren, Harriet A. J. Saunders, Andressa Pelster José, Ioanna Metallidou, Marèl F. M. Spoelstra
| Nature Verified
Abstract Taxanes are widely used chemotherapeutic agents that perturb cell division. They also exert effects during interphase, but the underlying mechanisms are poorly understood. Here we show that taxanes activate RhoA signalling and induce actin remodelling by releasing the RhoA activator GEF-H1 from microtubules. This taxane-induced release of GEF-H1 occurs rapidly, is independent of tubulin post-translational modifications, and can be recapitulated using purified proteins.
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