Irene Rosas Allende on Muck Rack

Irene Rosas Allende

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Articles

Landscape of copy number variants in Spanish people with dementia

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By Itziar de Rojas, Pablo García-González, Claudia Olive, Raquel Puerta, Laura Montrreal, Montserrat Alegret, Oscar Sotolongo-Grau, Amanda M. Cano, Marta Marquié, Sergi Valero, Miguel Calero, Alberto Rábano, Ana Pastor Verified, Teodoro del Ser, Inés Quintela, Juan Macias, Anaïs Corma-Gomez, Juan Pineda, Jose Royo, Silvia Mendoza, Carmen Lage, Carmen Antunez, Monica Diez-Fairen, Ignacio Alvarado Álvarez, Raquel Vilas, Manuel Menéndez-González, Carmen Rodriguez, Carmen Rodríguez Verified, Sebastián García-Madrona, Miquel Baquero, Jordi Pérez-Tur, Maria Bullido, Guillermo García-Ribas, Victoria Alvarez, Gerard Piñol-Ripoll, Eloy Rodriguez-Rodriguez, Jose María García-Alberca, Pablo Mir, Luis M. Real, Miguel Medina, Maria Saez, Ángel Carracedo, Michael T. Heneka, Mercè Boada, Pascual Sanchez-Juan, M. Fernández, Agustín Ruiz, Emilio Franco-Macías, Dolores Buiza-Rueda, María Bernal Sánchez-Arjona, Arturo Corbatón-Anchuelo, María Teresa Martínez-Larrad, Irene Rosas Allende, Ana Frank-García, Angel Martín-Montes, Lluís Tàrraga, Sven J. van der Lee
| Nature Verified
Abstract Recent studies suggest that copy number variants (CNVs) may contribute to the missing heritability of complex diseases such as Alzheimer’s disease (AD) and related dementias (ADRD). We performed a CNV analysis using genotyping data (Axiom 815 K Spanish biobank array) from the GR@ACE/DEGESCO dementia dataset (n = 20,067) of the Spanish population. Applying PennCNV and extensive quality control, 8275 controls and 7818 dementia cases were selected for gene-level case/control associations.
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