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Irfana Jan on Muck Rack

Irfana Jan

As seen in: Nature
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Articles

Inhibition of AXL receptor tyrosine kinase increases osteoblast function and bone mass

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By Mubashir Ahmad, Christoph Kölbl, Ann-Kristin Dorn, Burak Özkan, Florian olde Heuvel, Dilay Yilmaz, Alessa Wagner, Maja Vujić Spasić, Benjamin Krüger, Sooyeon Lee, Francesco Roselli, Anita Ignatius, Jan Tuckermann, Irfana Jan
| Nature Verified
Abstract Osteoporosis, a prevalent age-related disease, is characterized by impaired bone formation and an increased risk of fractures. Current anabolic treatments primarily rely on biologics, which are costly and require inconvenient administration. Identifying regulators of osteoblastogenesis that are amenable to small-molecule targeting is essential for developing more accessible therapies.
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