Irida Kastrati

Significance Click to copy section linkSection link copied! Pyridine nucleotide-disulfide oxidoreductases, such as thioredoxin reductase and glutathione reductase, play pivotal roles in regulating redox pathways across all organisms. Thioredoxin reductases stand out as crucial drug targets for cancer, infectious diseases, and inflammatory disorders, yet inhibiting them selectively poses a significant challenge.

Cancer Genes and Networks Irida Kastrati, Stacey E. P. Joosten, Svetlana E. Semina, Luis H. Alejo, Svitlana D. Brovkovych, Joshua D. Stender, Hugo M. Horlings, Marleen Kok, Elaine T. Alarid, Geoffrey L. Greene, Sabine C. Linn, Wilbert Zwart and Jonna Frasor DOI: 10.1158/1541-7786.MCR-19-1082 Published July 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.

Tumor Biology and Immunology Lamiaa El-Shennawy, Oleksii Dubrovskyi, Irida Kastrati, Jeanne M. Danes, Yiqun Zhang, Herbert E. Whiteley, Chad J. Creighton and Jonna Frasor DOI: 10.1158/0008-5472.CAN-17-1686 Published February 2018 Abstract A growing body of evidence suggests that the inflammatory NFκB pathway is associated with the progression of ER+ tumors to more aggressive stages. However, it is unknown whether NFκB is a driver or a consequence of aggressive ER+ disease.